Open AccessSelective Targeting of Gene Transfer to Vascular Endothelial Cells by Use of Peptides Isolated by Phage Display
Author(s) -
Stuart A. Nicklin,
Stephen J. White,
Sarah J. Watkins,
Robert E. Hawkins,
Andrew H. Baker
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.102.2.231
Subject(s) - biopanning , transduction (biophysics) , gene delivery , phage display , peptide library , biology , gene , umbilical vein , microbiology and biotechnology , adenoviridae , genetic enhancement , peptide , virology , peptide sequence , in vitro , biochemistry
Gene transfer to vascular cells is a highly inefficient and nonselective process, defined by the lack of specific cell-surface receptors for both nonviral and viral gene delivery vectors.
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