Pulmonary Capillary Endothelium-Bound Angiotensin-Converting Enzyme Activity in Acute Lung Injury | Zendy

Stylianos E. Orfanos | Zendy; Apostolos Armaganidis | Zendy; Constantinos Glynos | Zendy; Ekaterini Psevdi | Zendy; Panagiotis Kaltsas | Zendy; Paulina Sarafidou | Zendy; John D. Catravas | Zendy; Urania Dafni | Zendy; David Langleben | Zendy; Charis Roussos | Zendy

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Pulmonary Capillary Endothelium-Bound Angiotensin-Converting Enzyme Activity in Acute Lung Injury

Author(s) -

Stylianos E. Orfanos,

Apostolos Armaganidis,

Constantinos Glynos,

Ekaterini Psevdi,

Panagiotis Kaltsas,

Paulina Sarafidou,

John D. Catravas,

Urania Dafni,

David Langleben,

Charis Roussos

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.102.16.2011

Subject(s) - medicine , endothelium , lung , angiotensin converting enzyme , cardiology , peptidyl dipeptidase a , blood pressure

Pulmonary capillary endothelium-bound (PCEB) angiotensin-converting ectoenzyme (ACE) activity alteration is an early, sensitive, and quantifiable lung injury index in animal models. We hypothesized that (1) PCEB-ACE alterations can be found in patients with acute lung injury (ALI) and (2) PCEB-ACE activity correlates with the severity of lung injury and may be used as a quantifiable marker of the underlying pulmonary capillary endothelial dysfunction.

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