Alteration in Left Ventricular Diastolic Filling and Accumulation of Myocardial Collagen at Insulin-Resistant Prediabetic Stage of a Type II Diabetic Rat Model | Zendy

Katsufumi Mizushige | Zendy; Li Yao | Zendy; Takahisa Noma | Zendy; Hideyasu Kiyomoto | Zendy; Yang Yu | Zendy; Naohisa Hosomi | Zendy; Koji Ohmori | Zendy; Hirohíde Matsuo | Zendy

Open Access

Alteration in Left Ventricular Diastolic Filling and Accumulation of Myocardial Collagen at Insulin-Resistant Prediabetic Stage of a Type II Diabetic Rat Model

Author(s) -

Katsufumi Mizushige,

Li Yao,

Takahisa Noma,

Hideyasu Kiyomoto,

Yang Yu,

Naohisa Hosomi,

Koji Ohmori,

Hirohíde Matsuo

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.101.8.899

Subject(s) - medicine , endocrinology , histopathology , hyperinsulinemia , diastole , fibrosis , postprandial , diabetes mellitus , hydroxyproline , diabetic cardiomyopathy , blood pressure , cardiology , insulin resistance , heart failure , cardiomyopathy , pathology

Considerable controversy exists regarding impairment of cardiac function in diabetes mellitus (DM). We investigated the serial changes in left ventricular (LV) histopathology and LV filling dynamics in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which have been established as an animal model of type II DM.

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