Anti-Ischemic Effect of a Novel Cardioprotective Agent, JTV519, Is Mediated Through Specific Activation of δ-Isoform of Protein Kinase C in Rat Ventricular Myocardium | Zendy

Koichi Inagaki | Zendy; Yasuki Kihara | Zendy; Wataru Hayashida | Zendy; Toshiaki Izumi | Zendy; Yoshitaka Iwanaga | Zendy; Takeshi Yoneda | Zendy; Yuzo Takeuchi | Zendy; Katsuo Suyama | Zendy; Eri Muso | Zendy; Shigetake Sasayama | Zendy

Open Access

Anti-Ischemic Effect of a Novel Cardioprotective Agent, JTV519, Is Mediated Through Specific Activation of δ-Isoform of Protein Kinase C in Rat Ventricular Myocardium

Author(s) -

Koichi Inagaki,

Yasuki Kihara,

Wataru Hayashida,

Toshiaki Izumi,

Yoshitaka Iwanaga,

Takeshi Yoneda,

Yuzo Takeuchi,

Katsuo Suyama,

Eri Muso,

Shigetake Sasayama

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.101.7.797

Subject(s) - medicine , cardioprotection , creatine kinase , protein kinase c , ischemia , lactate dehydrogenase , gene isoform , reperfusion injury , pharmacology , cardiology , ischemic preconditioning , ventricular pressure , myocyte , kinase , enzyme , microbiology and biotechnology , biochemistry , hemodynamics , biology , gene

A new 1,4-benzothiazepine derivative, JTV519, has a strong protective effect against Ca(2+) overload-induced myocardial injury. We investigated the effect of JTV519 on ischemia/reperfusion injury in isolated rat hearts.

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