Induction of a Myocardial Adrenomedullin Signaling System During Ischemic Heart Failure in Rats | Zendy

Erik Øie | Zendy; Leif Erik Vinge | Zendy; Arne Yndestad | Zendy; Cecilie Sandberg | Zendy; Haakon K. Grøgaard | Zendy; Håvard Attramadal | Zendy

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Induction of a Myocardial Adrenomedullin Signaling System During Ischemic Heart Failure in Rats

Author(s) -

Erik Øie,

Leif Erik Vinge,

Arne Yndestad,

Cecilie Sandberg,

Haakon K. Grøgaard,

Håvard Attramadal

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.101.4.415

Subject(s) - adrenomedullin , medicine , heart failure , ventricle , endocrinology , myocardial infarction , endothelin receptor , receptor , carvedilol , endothelin 1 , cardiology

Increased plasma adrenomedullin (ADM) levels have been reported in congestive heart failure (HF). The present study was designed to investigate myocardial regulation of the different components of the ADM signaling system (ADM, ADM receptor, and receptor-activity-modifying protein-2, RAMP-2) during ischemic HF in rats and to identify the cells in the myocardium displaying ADM-like immunoreactivity (ADM-ir). Furthermore, the effects of endothelin (ET) receptor antagonism on expression of the myocardial ADM system during HF were investigated.

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