Angiotensin-Converting Enzyme Tissue Activity in the Diffuse In-Stent Restenotic Plaque | Zendy

Flavio Ribichini | Zendy; Francesco Pugno | Zendy; Valeria Ferrero | Zendy; Gianni Bussolati | Zendy; Germano Melissano | Zendy; Roberto Chiesa | Zendy; Carlo Di Mario | Zendy; Antonio Colombo | Zendy

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Angiotensin-Converting Enzyme Tissue Activity in the Diffuse In-Stent Restenotic Plaque

Author(s) -

Flavio Ribichini,

Francesco Pugno,

Valeria Ferrero,

Gianni Bussolati,

Germano Melissano,

Roberto Chiesa,

Carlo Di Mario,

Antonio Colombo

Publication year - 2000

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.101.2.e33

Subject(s) - cardiac catheterization , medicine , stent , right heart catheterization , hemodynamics

We present the 6-month anatomic, histological, and immunohistochemical (IHC) images of a diffuse and aggressive type of in-stent restenosis of a popliteal artery of a patient homozygous for the D (deletion) allele of the ACE gene (Figures 1⇓, 2⇓, and 3⇓).A detailed description of the histological changes of the arterial wall with time after coronary stenting in humans was published recently.1 These findings have confirmed that the ultrasound-detected “neointima” observed >1 month after implantation is composed primarily of smooth muscle cells (SMCs) and a proteoglycan-rich matrix. In the first weeks after stenting, …

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