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Staphylococcal α-Toxin Provokes Coronary Vasoconstriction and Loss in Myocardial Contractility in Perfused Rat Hearts
Author(s) -
Ulf Sibelius,
Ulrich Grandel,
Michael Buerke,
D Mueller,
Ladislau Kiss,
HansJoachim Kraemer,
Ruediger C. BraunDullaeus,
Werner Haberbosch,
Werner Seeger,
Friedrich Grimminger
Publication year - 2000
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.101.1.78
Subject(s) - medicine , contractility , vasoconstriction , cardiology
Cardiac performance is severely depressed in septic shock. Endotoxin has been implicated as the causative agent in Gram-negative sepsis, but similar abnormalities are encountered in Gram-positive sepsis. We investigated the influence of the major exotoxin of Staphylococcus aureus, staphylococcal alpha-toxin, in isolated perfused rat hearts.

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