Angiotensin II Induces LOX-1, the Human Endothelial Receptor for Oxidized Low-Density Lipoprotein | Zendy

Henning Morawietz | Zendy; Uwe Rueckschloss | Zendy; Bernd Niemann | Zendy; Nicole Duerrschmidt | Zendy; Jan Galle | Zendy; K. Hakim | Zendy; HansReinhard Zerkowski | Zendy; Tatsuya Sawamura | Zendy; Juergen Holtz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Angiotensin II Induces LOX-1, the Human Endothelial Receptor for Oxidized Low-Density Lipoprotein

Author(s) -

Henning Morawietz,

Uwe Rueckschloss,

Bernd Niemann,

Nicole Duerrschmidt,

Jan Galle,

K. Hakim,

HansReinhard Zerkowski,

Tatsuya Sawamura,

Juergen Holtz

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.100.9.899

Subject(s) - medicine , angiotensin ii , angiotensin ii receptor type 1 , endocrinology , receptor , lipoprotein , low density lipoprotein , cardiology , cholesterol

Oxidatively modified LDL (oxLDL) plays an important role in the development of atherosclerosis. OxLDL effects, eg, foam cell formation, are mediated in part by the classic scavenger receptor, whereas other effects may involve the recently cloned endothelial oxLDL receptor, LOX-1 (lectinlike oxLDL receptor-1), which is distinct from macrophage scavenger receptors. Because the regulation of LOX-1 must still be defined, we investigated whether LOX-1 is regulated by the potentially proatherosclerotic stimulant angiotensin II (Ang II).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research