Open AccessAminorex, Fenfluramine, and Chlorphentermine Are Serotonin Transporter Substrates
Author(s) -
Richard B. Rothman,
Mario Ayestas,
Christina M. Dersch,
Michael H. Baumann
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.8.869
Subject(s) - fenfluramine , phentermine , medicine , pharmacology , serotonin transporter , transporter , monoamine neurotransmitter , drug , serotonin , obesity , chemistry , biochemistry , receptor , weight loss , gene
Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough.
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