Aggregating Human Platelets Stimulate Expression of Vascular Endothelial Growth Factor in Cultured Vascular Smooth Muscle Cells Through a Synergistic Effect of Transforming Growth Factor-β 1 and Platelet-Derived Growth Factor AB | Zendy

Nicola Kronemann | Zendy; Anne Bouloumié | Zendy; S. Bassus | Zendy; C.M. Kirchmaier | Zendy; Rudi Busse | Zendy; Valérie B. SchiniKerth | Zendy

Open Access

Aggregating Human Platelets Stimulate Expression of Vascular Endothelial Growth Factor in Cultured Vascular Smooth Muscle Cells Through a Synergistic Effect of Transforming Growth Factor-β ₁ and Platelet-Derived Growth Factor _AB

Author(s) -

Nicola Kronemann,

Anne Bouloumié,

S. Bassus,

C.M. Kirchmaier,

Rudi Busse,

Valérie B. SchiniKerth

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.100.8.855

Subject(s) - medicine , platelet , growth factor , transforming growth factor , vascular smooth muscle , vascular endothelial growth factor , platelet derived growth factor , microbiology and biotechnology , vascular endothelial growth factor b , vascular endothelial growth factor c , smooth muscle , vascular endothelial growth factor a , immunology , platelet derived growth factor receptor , cancer research , vegf receptors , biology , receptor

Vascular endothelial growth factor (VEGF), an endothelial mitogen and chemoattractant, has been implicated in the recovery of the endothelium after balloon injury. The increased expression of VEGF in vascular smooth muscle cells (SMC) at sites of injury suggests that this cell type may be a major cellular source of VEGF. This study examined whether aggregating platelets stimulate VEGF expression in cultured SMC.

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