Open AccessEnhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina
Author(s) -
Pål Aukrust,
Fredrik Müller,
Thor Ueland,
Trude Berget,
E. Aaser,
Anne Brunsvig,
Nils Olav Solum,
Kolbjørn Forfang,
Stig S. Frøland,
Lars Gullestad
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.6.614
Subject(s) - medicine , unstable angina , platelet , cd40 , pathogenesis , platelet activation , angina , ex vivo , peripheral blood mononuclear cell , thrombin , cardiology , endocrinology , immunology , myocardial infarction , in vivo , in vitro , chemistry , biology , biochemistry , microbiology and biotechnology , cytotoxic t cell
The CD40 ligand (CD40L) on activated T cells and platelets may be activating matrix metalloproteinases, inducing procoagulant activity, and be involved in the pathogenesis of acute coronary syndromes by promoting plaque rupture in atheroma.
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