Open AccessAge-Dependent Association of Apolipoprotein E Genotype With Coronary and Aortic Atherosclerosis in Middle-Aged Men
Author(s) -
Erkki Ilveskoski,
Markus Perola,
Terho Lehtimäki,
Pékka Laippala,
Vesa Savolainen,
Jarkko Pajarinen,
Antti Penttilä,
Kaisa Lalu,
Antti Männikkö,
K. Liesto,
Timo Koivula,
Pekka J. Karhunen
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.6.608
Subject(s) - medicine , apolipoprotein e , genotype , coronary atherosclerosis , coronary arteries , cardiology , autopsy , apolipoprotein b , pathology , cholesterol , coronary artery disease , disease , artery , genetics , biology , gene
Apolipoprotein E (apoE) polymorphism is one of the genetic determinants of serum cholesterol values. The apoE epsilon4 allele has been associated with advanced coronary heart disease (CHD) diagnosed by angiography, but the role of the apoE genotype in atherosclerosis has not been confirmed at vessel-wall level, nor is any age-dependent effect of the apoE genotype on the development of CHD known.
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