Direct Detection of Heparin-Induced Platelet Aggregation | Zendy

Takefumi Matsuo | Zendy; Kazuomi Kario | Zendy

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Direct Detection of Heparin-Induced Platelet Aggregation

Author(s) -

Takefumi Matsuo,

Kazuomi Kario

Publication year - 1999

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.100.25.e155

Subject(s) - medicine , heparin , platelet aggregation , platelet , thrombin , agonist , unstable angina , receptor , coronary heart disease

To the Editor: Enhanced platelet aggregation responses to stimulation with ADP or thrombin receptor agonist peptides (TRAP) have been observed during heparin therapy in patients with unstable angina. However, the platelet aggregation curve in Figure 3 of the article by Xiao and Theroux1 was not obtained from a direct detection to evaluate heparin-induced hyperaggregation.A new platelet aggregometer (AG-10; Kowa, Japan) that uses a laser-light-scattering beam was introduced.2 Platelet aggregates, the size of which was measured as total voltage of …

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