Open AccessNitrate Resistance In Platelets From Patients With Stable Angina Pectoris
Author(s) -
Yuliy Y. Chirkov,
Andrew Holmes,
Larissa Chirkova,
John D. Horowitz
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.2.129
Subject(s) - sodium nitroprusside , medicine , platelet , nitric oxide , superoxide dismutase , endocrinology , platelet activation , hemodynamics , pharmacology , cardiology , oxidative stress
Hemodynamic resistance to nitrates has been previously documented in congestive heart failure. In patients with stable angina pectoris (SAP), we have observed a similar phenomenon: decreased platelet response to disaggregating effects of nitroglycerin (NTG) and sodium nitroprusside (SNP).
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