Open AccessReduction in Vascular Lesion Formation by Hirudin Secreted From Retrovirus-Transduced Confluent Endothelial Cells on Vascular Grafts in Baboons
Author(s) -
Anders Lundell,
Andrew B. Kelly,
Johanna S. Anderson,
Monique M.H. Marijianowski,
Jeffrey J. Rade,
Stephen R. Hanson,
Laurence A. Harker
Publication year - 1999
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.100.19.2018
Subject(s) - medicine , hirudin , lesion , pathology , retrovirus , virology , immunology , virus , thrombin , platelet
The hypothesis that thrombin mediates the formation of neointimal vascular lesions at sites of mechanical vascular injury has been tested in baboons by measurement of the effects of hirudin delivered by retrovirus-transduced hirudin-secreting vascular endothelial cells (ECs) lining surgically implanted arterial vascular grafts (AVGs).
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