Treatment of Angina Pectoris with Cinchona Alkaloids | Zendy

Joseph E.F. Riseman | Zendy; LESTER A. STEINBERG | Zendy; George E. Altman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Treatment of Angina Pectoris with Cinchona Alkaloids

Author(s) -

Joseph E.F. Riseman,

LESTER A. STEINBERG,

George E. Altman

Publication year - 1954

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.10.6.809

Subject(s) - quinidine , medicine , quinine , pharmacology , angina , drug , vasodilation , verapamil , calcium , myocardial infarction , malaria , immunology

Reports indicating the value of quinidine sulfate in angina pectoris led to (1) a search for related drugs which were equally effective but less toxic, and (2) a study of the mode of action of these drugs. It was found that quinidine, quinine, cinchonadine, and cinchamidine decrease the frequency of attacks in daily life and increase the exercise tolerance as measured by a standardized test. Quinine sulfate (0.3 to 0.4 Gm. every eight hours) appears to be the drug of choice from the standpoint of availability and low toxicity as well as effectiveness. The value of these drugs is apparently due to a vasodilating action which in turn is dependent on the presence of the quinoline ring.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research