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Previous observations have demonstrated a depression in cerebral blood flow during controlled hypotension with ganglionic blocking agents. Cerebral blood flow is also decreased when normotensive individuals are made hypertensive by the administration of vasopressor agents. The opposite response is observed when hypotensive individuals are made normotensive by the administration of these same agents, in which circumstance cerebral blood flow is increased.

A Comparison of the Cerebral Hemodynamic Response to Aramine and Norepinephrine in the Normotensive and the Hypotensive Subject