Open AccessClinical Studies on Veratrum Alkaloids
Author(s) -
Edward Meilman,
Otto Krayer
Publication year - 1950
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.1.2.204
Subject(s) - medicine , veratridine , blood pressure , pharmacology , reflex , anesthesia , traditional medicine , cardiology , sodium , sodium channel , chemistry , organic chemistry
The action of two pure veratrum alkaloids, veratridine and protoveratrine, in human hypertension is described for the first time. The vasodepressor reflex pathway involved in the response to these ester alkaloids is reviewed. Protoveratrine is found to produce a striking fall in blood pressure in both essential and renal hypertension after intravenous administration.
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