Targeted Proteolysis Sustains Calcineurin Activation | Zendy

Natalie Burkard | Zendy; Jan Becher | Zendy; Cornelia Heindl | Zendy; Ludwig Neyses | Zendy; Kai Schuh | Zendy; Oliver Ritter | Zendy

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Targeted Proteolysis Sustains Calcineurin Activation

Author(s) -

Natalie Burkard,

Jan Becher,

Cornelia Heindl,

Ludwig Neyses,

Kai Schuh,

Oliver Ritter

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.0000156458.80515.f7

Subject(s) - calpain , proteolysis , stimulation , calcineurin , cytosol , microbiology and biotechnology , angiotensin ii , biochemistry , chemistry , endocrinology , medicine , biology , receptor , enzyme , transplantation

Calcineurin (CnA) is important in the regulation of myocardial hypertrophy. We demonstrated that targeted proteolysis of the CnA autoinhibitory domain under pathological myocardial workload leads to increased CnA activity in human myocardium. Here, we investigated the proteolytic mechanism leading to activation of CnA.

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