Local Gene Transfer of phVEGF-2 Plasmid by Gene-Eluting Stents | Zendy

Dirk Walter | Zendy; Manfred Cejna | Zendy; Larry J. DíazSandoval | Zendy; Sean L. Willis | Zendy; Laura C Kirkwood | Zendy; Peter W. Stratford | Zendy; Anne Barbara Tietz | Zendy; Rudolf Kirchmair | Zendy; Marcy Silver | Zendy; Cindy Curry | Zendy; Andrea Wecker | Zendy; Youngsup Yoon | Zendy; Regina Heidenreich | Zendy; Allison Hanley | Zendy; Marianne Kearney | Zendy; Fermin O. Tio | Zendy; Patrik Kuenzler | Zendy; Jeffrey M. Isner | Zendy; Douglas W. Losordo | Zendy

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Local Gene Transfer of phVEGF-2 Plasmid by Gene-Eluting Stents

Author(s) -

Dirk Walter,

Manfred Cejna,

Larry J. DíazSandoval,

Sean L. Willis,

Laura C Kirkwood,

Peter W. Stratford,

Anne Barbara Tietz,

Rudolf Kirchmair,

Marcy Silver,

Cindy Curry,

Andrea Wecker,

Youngsup Yoon,

Regina Heidenreich,

Allison Hanley,

Marianne Kearney,

Fermin O. Tio,

Patrik Kuenzler,

Jeffrey M. Isner,

Douglas W. Losordo

Publication year - 2004

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.0000133324.38115.0a

Subject(s) - medicine , gene transfer , plasmid , gene , genetic enhancement , cardiology , genetics , biology

Drug-eluting stents represent a useful strategy for the prevention of restenosis using various antiproliferative drugs. These strategies share the liability of impairing endothelial recovery, thereby altering the natural biology of the vessel wall and increasing the associated risk of stent thrombosis. Accordingly, we tested the hypothesis that local delivery via gene-eluting stent of naked plasmid DNA encoding for human vascular endothelial growth factor (VEGF)-2 could achieve similar reductions in neointima formation while accelerating, rather than inhibiting, reendothelialization.

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