Open AccessNuclear Factor-κB Protects the Adult Cardiac Myocyte Against Ischemia-Induced Apoptosis in a Murine Model of Acute Myocardial Infarction
Author(s) -
Arunima Misra,
Sandra B. Haudek,
Pascal Knuefermann,
Jesús G. Vallejo,
Zhijian J. Chen,
Lloyd H. Michael,
Natarajan Sivasubramanian,
Eric N. Olson,
Mark L. Entman,
Douglas L. Mann
Publication year - 2003
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.0000108929.93074.0b
Subject(s) - medicine , myocyte , apoptosis , tumor necrosis factor alpha , superoxide dismutase , genetically modified mouse , endocrinology , ischemia , cardiac myocyte , myocardial infarction , transgene , oxidative stress , biology , biochemistry , gene
Previous studies have shown that tumor necrosis factor (TNF) confers cytoprotective responses in cardiac myocytes. However, the mechanisms for the cytoprotective effects of TNF remain unknown. Given that TNF signals through nuclear factor kappaB (NF-kappaB) and given that NF-kappaB mediates cytoprotective responses, we asked whether NF-kappaB activation conferred cytoprotective responses in acute myocardial ischemia/infarction.