Evidence for Dysregulation of Dimethylarginine Dimethylaminohydrolase I in Chronic Hypoxia–Induced Pulmonary Hypertension | Zendy

Lesley J. Millatt | Zendy; Guy Whitley | Zendy; Dechun Li | Zendy; James Leiper | Zendy; Helmy M. Siragy | Zendy; Robert M. Carey | Zendy; Roger A. Johns | Zendy

Open Access

Evidence for Dysregulation of Dimethylarginine Dimethylaminohydrolase I in Chronic Hypoxia–Induced Pulmonary Hypertension

Author(s) -

Lesley J. Millatt,

Guy Whitley,

Dechun Li,

James Leiper,

Helmy M. Siragy,

Robert M. Carey,

Roger A. Johns

Publication year - 2003

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.0000089087.25930.ff

Subject(s) - asymmetric dimethylarginine , pulmonary hypertension , hypoxia (environmental) , medicine , western blot , endocrinology , nitric oxide , nitric oxide synthase , lung , hypoxic pulmonary vasoconstriction , enzyme , chemistry , arginine , biochemistry , oxygen , amino acid , organic chemistry , gene

Chronic hypoxia-induced pulmonary hypertension is associated with increased pulmonary expression of nitric oxide synthase (NOS) enzymes. Nevertheless, some reports have indicated decreased pulmonary production of NO in the disease. To address this paradox, we determined pulmonary concentrations of the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) in the hypoxia-induced pulmonary hypertension rat model. In addition, we determined whether dysregulation of the ADMA-metabolizing enzyme dimethylarginine dimethylaminohydrolase I (DDAH I) plays a role in this disease.

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