Open AccessThrombospondin-4 and Its Variants
Author(s) -
Olga SteninaAdognravi,
Shailesh Y. Desai,
Irene Krukovets,
Kelly Kight,
Damir Janigro,
Eric J. Topol,
Edward F. Plow
Publication year - 2003
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.0000089085.76320.4e
Subject(s) - vascular smooth muscle , thrombospondin 1 , thrombospondin , phosphorylation , cell growth , medicine , microbiology and biotechnology , cancer research , biology , metalloproteinase , biochemistry , angiogenesis , smooth muscle , matrix metalloproteinase
In a recent large-scale genetic association study, a single nucleotide polymorphism in the thrombospondin-4 (TSP-4) gene, resulting in a proline-for-alanine substitution at position 387, was associated with a significantly increased risk for premature atherosclerosis. TSP-4 had not previously been implicated in vascular pathology, and very little information is available on its expression and functions.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom