Cytosolic Heat Shock Protein 60, Hypoxia, and Apoptosis | Zendy

S. Gupta | Zendy; Anne A. Knowlton | Zendy

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Cytosolic Heat Shock Protein 60, Hypoxia, and Apoptosis

Author(s) -

S. Gupta,

Anne A. Knowlton

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.0000038112.64503.6e

Subject(s) - hsp60 , cytosol , mitochondrion , cytochrome c , heat shock protein , apoptosis , microbiology and biotechnology , hypoxia (environmental) , biology , biochemistry , hsp70 , chemistry , oxygen , enzyme , organic chemistry , gene

Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that HSP60 would decrease with hypoxia/reoxygenation and that this would precipitate bax translocation to the mitochondria and release of cytochrome c.

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