Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis | Zendy

E. Karin Arkenbout | Zendy; Vivian de Waard | Zendy; Maaike van Bragt | Zendy; Tanja A.E. van Achterberg | Zendy; Jos Grimbergen | Zendy; Bruno Pichon | Zendy; Hans Pannekoek | Zendy; Carlie J.M. de Vries | Zendy

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Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis

Author(s) -

E. Karin Arkenbout,

Vivian de Waard,

Maaike van Bragt,

Tanja A.E. van Achterberg,

Jos Grimbergen,

Bruno Pichon,

Hans Pannekoek,

Carlie J.M. de Vries

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.0000028811.03056.bf

Subject(s) - transcription factor , neuron derived orphan receptor 1 , orphan receptor , nuclear receptor , subfamily , vascular smooth muscle , biology , microbiology and biotechnology , medicine , cancer research , endocrinology , genetics , gene , smooth muscle

Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear receptor of T cells (NOT) are a subfamily of transcription factors belonging to the nuclear receptor superfamily and are induced in activated SMCs. In this study, we investigated the role of these transcription factors in SMC proliferation in atherogenesis.

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