Ag(c): recognition by a monoclonal antibody. | Zendy

Miguel T. Robinson | Zendy; Verne N. Schumaker | Zendy; R. Bütler | Zendy; Kimberley Berg | Zendy; Linda K. Curtiss | Zendy

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Ag(c): recognition by a monoclonal antibody.

Author(s) -

Miguel T. Robinson,

Verne N. Schumaker,

R. Bütler,

Kimberley Berg,

Linda K. Curtiss

Publication year - 1986

Publication title -

arteriosclerosis an official journal of the american heart association inc

Language(s) - English

Resource type - Journals

eISSN - 2330-9180

pISSN - 0276-5047

DOI - 10.1161/01.atv.6.3.341

Subject(s) - apolipoprotein b , epitope , monoclonal antibody , biology , antibody , gene , microbiology and biotechnology , allele , genetics , chemistry , biochemistry , cholesterol

A monoclonal antibody directed against human apolipoprotein B, which was previously shown in family studies to detect allelic variations (J Biol Chem 1984; 259:6423-6430), has now been identified with the Ag(c) factor. This identification allows the location of the Ag system on the structural gene for apolipoprotein B and on the short arm of human chromosome 2. The epitope corresponding to Ag(c) is located within the amino acid sequence common to apolipoproteins B-100 and B-48. Since a single molecule of apolipoprotein B-100 is present on human LDL, individual LDL possesses either the epitope corresponding to Ag(c) or that corresponding to Ag(g). These studies on allelic variation among human apolipoprotein B species parallel similar studies in animals in which a relationship to atherosclerosis was found.

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