Human apolipoprotein A-I--C-III gene complex is located on chromosome 11. | Zendy

G.A.P. Bruns | Zendy; Sotirios K. Karathanasis | Zendy; Jan L. Breslow | Zendy

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Human apolipoprotein A-I--C-III gene complex is located on chromosome 11.

Author(s) -

G.A.P. Bruns,

Sotirios K. Karathanasis,

Jan L. Breslow

Publication year - 1984

Publication title -

arteriosclerosis an official journal of the american heart association inc

Language(s) - English

Resource type - Journals

eISSN - 2330-9180

pISSN - 0276-5047

DOI - 10.1161/01.atv.4.2.97

Subject(s) - gene , southern blot , genetics , biology , chromosome , human genome , somatic cell , genome , gene mapping , microbiology and biotechnology

The genes for two of the apolipoproteins, apo A-I and apo C-III, previously shown to be within 3kb in the genome, were localized to human chromosome 11 by Southern blot analysis of DNA from human-rodent somatic cell hybrids. These two genes were shown to exhibit polymorphisms associated with dyslipoproteinemia and premature atherosclerosis, and it will now be possible to examine the relationship of these genes to the many others that have been assigned to this chromosome.

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