Endothelial regeneration in hypertensive and genetically hypercholesterolemic rats. | Zendy

Margaret F. Prescott | Zendy; Kurt Müller | Zendy

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Endothelial regeneration in hypertensive and genetically hypercholesterolemic rats.

Author(s) -

Margaret F. Prescott,

Kurt Müller

Publication year - 1983

Publication title -

arteriosclerosis an official journal of the american heart association inc

Language(s) - English

Resource type - Journals

eISSN - 2330-9180

pISSN - 0276-5047

DOI - 10.1161/01.atv.3.3.206

Subject(s) - thickening , regeneration (biology) , medicine , endothelial dysfunction , cardiology , endocrinology , chemistry , biology , microbiology and biotechnology , polymer science

Endothelial regeneration after a narrow, superficial aortic injury was studied in rats with chronic Goldblatt hypertension, genetic hypercholesterolemia, or a combination of hypertension and genetic hypercholesterolemia. In all groups, endothelial continuity was restored within 24 to 36 hours by a combination of endothelial migration and proliferation. A line of increased endothelial density covering the previous wound was seen through 16 weeks after injury. Intimal thickening after injury did not occur in any of the groups. These results indicate that hypertension and hypercholesterolemia neither delay endothelial regeneration nor cause intimal thickening after a small injury in the rat.

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