Complex Compound with Transitional Metal of Akway Bark (Drimys piperita Hook F.) as Low Molecular Weight Scavenging Antioxidant: A Computational Study | Zendy

Hostalige Hutasoit | Zendy; D.J.D.H. Djoko | Zendy; Sutiman Bambang Sumitro | Zendy; Simon Bambang Widjanarko | Zendy

Open Access

Complex Compound with Transitional Metal of Akway Bark (Drimys piperita Hook F.) as Low Molecular Weight Scavenging Antioxidant: A Computational Study

Author(s) -

Hostalige Hutasoit,

D.J.D.H. Djoko,

Sutiman Bambang Sumitro,

Simon Bambang Widjanarko

Publication year - 2021

Publication title -

journal of tropical life science

Language(s) - English

Resource type - Journals

eISSN - 2527-4376

pISSN - 2087-5517

DOI - 10.11594/jtls.11.03.02

Subject(s) - chemistry , scavenging , scavenger , antioxidant , free radical scavenger , bark (sound) , nuclear chemistry , organic chemistry , biology , ecology

Akway (Drimys piperita Hook f.) was known as an endogenous plant of Indonesia. This plant was investigated as free radical scavenger based on paramagnetic properties. This study aimed to identify the bioactive compound and the role of Fe metals ions to enhance the free radical scavenger capacity as Low molecular weight antioxidant (LWMA) of akway. This study was designed by ultra-performance liquid chromatography (UPLC) coupled with ultra-high-resolution time of flight-mass spectrometry detector (TOF-MS), docking (Pyrex and Discovery Studio 2016 Client) and pharmacokinetic properties prediction (SwissADME). UPLC-TOF-MS analysis showed that herbal akway bark has five molecular formula (C4H3N10O21-, C14H19N4O91-, C4H7N6O51-, C15H28NO31+, and C23H32NO71+). The docking was illustrated the complex binding akway formula with Fe and its role as a metal donor and metal acceptor. It also confirmed on pharmacokinetics properties prediction which molecular compounds of akway have aqueous solubility. It meant the herbal akway bark complexed to Fe could be a low molecular weight antioxidant and it could be escalated free radical scavenger capacity

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research