Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. | Zendy

Nina Artanti | Zendy; Muhammad Hanafi | Zendy; Rina Andriyani | Zendy; Vienna Saraswaty | Zendy; Linar Z. Udin | Zendy; Puspa Dewi Lotulung | Zendy; Ken Ichi Fujita | Zendy; Yoshinosuke Usuki | Zendy

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Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.

Author(s) -

Nina Artanti,

Muhammad Hanafi,

Rina Andriyani,

Vienna Saraswaty,

Linar Z. Udin,

Puspa Dewi Lotulung,

Ken Ichi Fujita,

Yoshinosuke Usuki

Publication year - 2015

Publication title -

journal of tropical life science

Language(s) - English

Resource type - Journals

eISSN - 2527-4376

pISSN - 2087-5517

DOI - 10.11594/jtls.05.02.06

Subject(s) - ic50 , hl60 , traditional medicine , chemistry , cancer cell lines , column chromatography , human breast , ethyl acetate , chromatography , cancer cell , botany , biology , cancer , in vitro , biochemistry , medicine , genetics

Hedyotis corymbosa L., with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine. The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC 50 of 6.51 µg/mL. The methylene chloride fraction shows a potential cytotoxic activity with an IC 50 of 2.75 µg/mL. To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC 50 values of 0.7; 11.0 and 104.2 µg/mL, respectively. Based on the 1D and 2D FTNMR data, the isolated compound is an asperuloside.

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