The Curative Activity of Isolated Fraction from Spathodea campanulata Beauv Stem Bark on Rats Exposed to Benzopyrene | Zendy

Masruri Masruri | Zendy; Mohamad Lutfillah | Zendy; Ady Sumaryanto | Zendy; Rurini Retnowati | Zendy; Aulanni’am Aulanni’am | Zendy

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The Curative Activity of Isolated Fraction from Spathodea campanulata Beauv Stem Bark on Rats Exposed to Benzopyrene

Author(s) -

Masruri Masruri,

Mohamad Lutfillah,

Ady Sumaryanto,

Rurini Retnowati,

Aulanni’am Aulanni’am

Publication year - 2014

Publication title -

journal of tropical life science

Language(s) - English

Resource type - Journals

eISSN - 2527-4376

pISSN - 2087-5517

DOI - 10.11594/jtls.04.03.01

Subject(s) - benzopyrene , malondialdehyde , bark (sound) , histology , biology , botany , chemistry , fraction (chemistry) , secondary metabolite , traditional medicine , biochemistry , carcinogen , antioxidant , benzo(a)pyrene , medicine , chromatography , gene , ecology , genetics

This paper reports a screening results of the secondary metabolites composed in Spathodea campanulata Beauv stem bark, evaluate inhibiting activity of malondialdehyde (MDA) on rats cancer model exposed with benzopyrene, and the histology of its lung. The secondary metabolite of the stem bark fraction consisted of alkaloids, flavonoids-phenolic, terpenoid and steroid compounds. The isolated fraction contained of these metabolites significantly indicate bioactivity by reducting of malondialdehyde (MDA) level, and also histology appearance of the lung tissue prepared from the benzopyrene-exposed rat indicated a curative activity.

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