High Tissue TLR5 Expression Predicts Better Outcomes in Colorectal Cancer Patients | Zendy

Ines BeilmannLehtonen | Zendy; Jaana Hagström | Zendy; Harri Mustonen | Zendy; Selja Koskensalo | Zendy; Caj Haglund | Zendy; Camilla Böckelman | Zendy

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High Tissue TLR5 Expression Predicts Better Outcomes in Colorectal Cancer Patients

Author(s) -

Ines BeilmannLehtonen,

Jaana Hagström,

Harri Mustonen,

Selja Koskensalo,

Caj Haglund,

Camilla Böckelman

Publication year - 2021

Publication title -

oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.987

H-Index - 98

eISSN - 1423-0232

pISSN - 0030-2414

DOI - 10.1159/000516543

Subject(s) - tlr5 , medicine , colorectal cancer , tissue microarray , cancer , oncology , proportional hazards model , log rank test , survival analysis , gastroenterology , receptor , toll like receptor , innate immune system

Colorectal cancer (CRC), the third most common cancer globally, caused 881,000 cancer deaths in 2018. Toll-like receptors (TLRs), the primary sensors of pathogen-associated molecular patterns and damage-associated molecular patterns, activate innate and adaptive immune systems and participate in the development of an inflammatory tumor microenvironment. We aimed to explore the prognostic value of TLR3, TLR5, TLR7, and TLR9 tissue expressions in CRC patients.

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