Dermal Penetration Analysis of Curcumin in an ex vivo Porcine Ear Model Using Epifluorescence Microscopy and Digital Image Processing | Zendy

Olga Pelikh | Zendy; Shashank Reddy Pinnapireddy | Zendy; Cornelia M. Keck | Zendy

Open Access

Dermal Penetration Analysis of Curcumin in an ex vivo Porcine Ear Model Using Epifluorescence Microscopy and Digital Image Processing

Author(s) -

Olga Pelikh,

Shashank Reddy Pinnapireddy,

Cornelia M. Keck

Publication year - 2021

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000514498

Subject(s) - curcumin , penetration (warfare) , ex vivo , in vivo , chemistry , pharmacology , biomedical engineering , in vitro , biochemistry , mathematics , biology , medicine , microbiology and biotechnology , operations research

Curcumin is a promising drug candidate, but its use for dermal application is limited due to its poor aqueous solubility. Thus, formulations that increase the solubility of curcumin are needed to fully exploit the therapeutic potential of curcumin. Various previous studies address this issue, but a comparison of the efficacy between these formulations remains difficult. The reason for this is a missing standard formulation as benchmark control and an easy-to-use skin penetration model that allows for a fast discrimination between different formulations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research