Cellular Senescence Is Associated with Faster Progression of Focal Segmental Glomerulosclerosis | Zendy

Daniela Verzola | Zendy; Michela Saio | Zendy; Daniela Picciotto | Zendy; Francesca Viazzi | Zendy; Elisa Russo | Zendy; Leda Cipriani | Zendy; Annalisa Carta | Zendy; Francesca Costigliolo | Zendy; Gabriele Gaggero | Zendy; Gennaro Salvidio | Zendy; Pasquale Esposito | Zendy; Giacomo Garibotto | Zendy; Laura Poggi | Zendy

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Cellular Senescence Is Associated with Faster Progression of Focal Segmental Glomerulosclerosis

Author(s) -

Daniela Verzola,

Michela Saio,

Daniela Picciotto,

Francesca Viazzi,

Elisa Russo,

Leda Cipriani,

Annalisa Carta,

Francesca Costigliolo,

Gabriele Gaggero,

Gennaro Salvidio,

Pasquale Esposito,

Giacomo Garibotto,

Laura Poggi

Publication year - 2020

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000511560

Subject(s) - proteinuria , focal segmental glomerulosclerosis , medicine , senescence , glomerulosclerosis , nephrology , kidney disease , renal function , kidney , pathology , endocrinology

A current, albeit unproven, hypothesis is that an acceleration of cellular senescence is involved in impaired renal repair and progression of glomerular diseases. Focal segmental glomerulosclerosis (FSGS) is a glomerular disease with a substantial risk for progression to ESRD. However, if and to what extent cell senescence predicts a negative outcome in FSGS is still unknown.

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