Investigation of ex vivo Skin Penetration of Coenzyme Q10 from Microemulsions and Hydrophilic Cream | Zendy

Efrem N. Tessema | Zendy; Konstanze Bosse | Zendy; Johannes Wohlrab | Zendy; Yahya Mrestani | Zendy; Reinhard H.H. Neubert | Zendy

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Investigation of ex vivo Skin Penetration of Coenzyme Q10 from Microemulsions and Hydrophilic Cream

Author(s) -

Efrem N. Tessema,

Konstanze Bosse,

Johannes Wohlrab,

Yahya Mrestani,

Reinhard H.H. Neubert

Publication year - 2020

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000511443

Subject(s) - coenzyme q10 , chemistry , penetration (warfare) , dermis , human skin , cosmeceutical , photoaging , ex vivo , epidermis (zoology) , microemulsion , chromatography , pharmacology , biochemistry , dermatology , biology , in vitro , medicine , pulmonary surfactant , genetics , microbiology and biotechnology , operations research , engineering , anatomy

Coenzyme Q10 (CoQ10) has been widely used in topical and cosmeceutical products due to its cutaneous antioxidant and energizer effects. CoQ10 is found in a higher concentration in the epidermis compared to dermis. The epidermal level of CoQ10 can be reduced due to several factors such as skin UV irradiation and photoaging. Various dermal nano-formulations have been investigated to overcome the skin barrier and enhance the poor penetration of CoQ10. The nanocarriers are designed to target and concentrate the CoQ10 in the viable epidermis. Most of these studies, however, failed to show the depth and extent of penetration of CoQ10 from the various carrier systems.

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