The Effects of Deep Brain Stimulation of the Subthalamic Nucleus on Vascular Endothelial Growth Factor, Brain-Derived Neurotrophic Factor, and Glial Cell Line-Derived Neurotrophic Factor in a Rat Model of Parkinson’s Disease | Zendy

Katharina Faust | Zendy; Peter Vajkoczy | Zendy; Xi Bai | Zendy; Daniel Harnack | Zendy

Open Access

The Effects of Deep Brain Stimulation of the Subthalamic Nucleus on Vascular Endothelial Growth Factor, Brain-Derived Neurotrophic Factor, and Glial Cell Line-Derived Neurotrophic Factor in a Rat Model of Parkinson’s Disease

Author(s) -

Katharina Faust,

Peter Vajkoczy,

Xi Bai,

Daniel Harnack

Publication year - 2020

Publication title -

stereotactic and functional neurosurgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.798

H-Index - 63

eISSN - 1423-0372

pISSN - 1011-6125

DOI - 10.1159/000511121

Subject(s) - glial cell line derived neurotrophic factor , neurotrophic factors , deep brain stimulation , vascular endothelial growth factor , brain derived neurotrophic factor , stimulation , neuroprotection , medicine , parkinson's disease , neuroscience , endocrinology , psychology , receptor , disease , vegf receptors

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has evolved as a powerful therapeutic alternative for the treatment of Parkinson's disease (PD). Despite its clinical efficacy, the mechanisms of action have remained poorly understood. In addition to the immediate symptomatic effects, long-term neuroprotective effects have been suggested. Those may be mediated through neurotrophic factors (NFs) like vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF). Here, the impact of DBS on the expression of NFs was analysed in a rat model of PD.

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