High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases | Zendy

Reetta Peltonen | Zendy; Jaana Hagström | Zendy; Taina Tervahartiala | Zendy; Timo Sorsa | Zendy; Caj Haglund | Zendy; Helena Isoniemi | Zendy

Open Access

High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases

Author(s) -

Reetta Peltonen,

Jaana Hagström,

Taina Tervahartiala,

Timo Sorsa,

Caj Haglund,

Helena Isoniemi

Publication year - 2020

Publication title -

oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.987

H-Index - 98

eISSN - 1423-0232

pISSN - 0030-2414

DOI - 10.1159/000510609

Subject(s) - medicine , colorectal cancer , matrix metalloproteinase , myeloperoxidase , immunohistochemistry , cancer , pathology , gastroenterology , oncology , inflammation

The liver metastases of colorectal cancer (CRC) can be surgically treated in selected cases, with continuously improving results. Matrix metalloproteinases (MMPs) contribute to cancer invasion by degrading the extracellular matrix, and elevated levels of MMP-2, MMP-8, and MMP-9 have been detected in several malignancies. Myeloperoxidase (MPO) is a mediator of tissue damage that can oxidatively activate latent MMPs. We evaluated the prognostic value of MMP-2, MMP-8, and MMP-9 in tissue samples of primary tumors and liver metastases and the pre- and postoperative serum levels of MMP-8, MMP-9, and MPO in CRC patients undergoing liver resection.

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