Recommendations on Surveillance for Differentiated Thyroid Carcinoma in Children with PTEN Hamartoma Tumor Syndrome | Zendy

Leon Jonker | Zendy; Chantal A Lebbink | Zendy; Marjolijn C.J. Jongmans | Zendy; Rutger A. J. Nievelstein | Zendy; Johannes H. M. Merks | Zendy; E.J.M. Nieveen van Dijkum | Zendy; Thera P. Links | Zendy; Nicoline Hoogerbrugge | Zendy; A.S. Paul van Trotsenburg | Zendy; Hanneke M. van Santen | Zendy

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Recommendations on Surveillance for Differentiated Thyroid Carcinoma in Children with PTEN Hamartoma Tumor Syndrome

Author(s) -

Leon Jonker,

Chantal A Lebbink,

Marjolijn C.J. Jongmans,

Rutger A. J. Nievelstein,

Johannes H. M. Merks,

E.J.M. Nieveen van Dijkum,

Thera P. Links,

Nicoline Hoogerbrugge,

A.S. Paul van Trotsenburg,

Hanneke M. van Santen

Publication year - 2020

Publication title -

european thyroid journal

Language(s) - English

Resource type - Journals

eISSN - 2235-0802

pISSN - 2235-0640

DOI - 10.1159/000508872

Subject(s) - medicine , cowden syndrome , thyroid carcinoma , pten , thyroid cancer , thyroid , incidence (geometry) , oncology , pediatrics , cohort , genetics , apoptosis , physics , pi3k/akt/mtor pathway , optics , biology

PTEN hamartoma tumor syndrome (PHTS) represents a group of syndromes caused by a mutation in the PTEN gene. Children with a germline PTEN mutation have an increased risk of developing differentiated thyroid carcinoma (DTC). Several guidelines have focused on thyroid surveillance in these children, but studies substantiating these recommendations are lacking.

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