Diagnostic Impact of CSF Biomarkers in a Local Hospital Memory Clinic Revisited | Zendy

Leo Boelaarts | Zendy; Jos F. M. de Jonghe | Zendy; Philip Scheltens | Zendy

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Diagnostic Impact of CSF Biomarkers in a Local Hospital Memory Clinic Revisited

Author(s) -

Leo Boelaarts,

Jos F. M. de Jonghe,

Philip Scheltens

Publication year - 2020

Publication title -

dementia and geriatric cognitive disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.026

H-Index - 110

eISSN - 1421-9824

pISSN - 1420-8008

DOI - 10.1159/000506332

Subject(s) - medicine , cerebrospinal fluid , memory clinic , prospective cohort study , dementia , diagnostic accuracy , biomarker , diagnostic test , disease , pediatrics , gastroenterology , biochemistry , chemistry

Research guidelines on predicting and diagnosing Alzheimer's disease (AD) acknowledge cerebrospinal fluid (CSF) levels as pivotal biomarkers. We studied the usefulness of CSF biomarkers in the diagnostic workup of patients in a geriatric outpatient memory clinic of a community-based hospital, attempted to determine a cutoff age for the use of CSF biomarkers in this group of patients, and compared the total τ/Aβ ratio as an alternative CSF diagnostic rule with the usual rules for interpreting CSF levels.

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