Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin | Zendy

Anna Lena Klein | Zendy; Markus Lubda | Zendy; Paniz Akbarzadeh Taghavi | Zendy; Jürgen Lademann | Zendy; Ingeborg Beckers | Zendy; Jörg von Hagen | Zendy; Harald Kolmar | Zendy; Alexa Patzelt | Zendy

Open Access

Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin

Author(s) -

Anna Lena Klein,

Markus Lubda,

Paniz Akbarzadeh Taghavi,

Jürgen Lademann,

Ingeborg Beckers,

Jörg von Hagen,

Harald Kolmar,

Alexa Patzelt

Publication year - 2020

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000505839

Subject(s) - penetration (warfare) , varnish , caffeine , chemistry , pipette , fluorescein , chromatography , biomedical engineering , medicine , physics , organic chemistry , operations research , quantum mechanics , engineering , fluorescence , coating

The skin represents a drug delivery portal. The establishment of a skin model capable of distinguishing between the follicular and intercellular penetration pathways remains a challenge. The study described herein was aimed at showing the influence of two nail varnishes as closure material and four application techniques to spread the active pharmaceutical ingredient (API) on a successful follicular closure without inducing penetration-enhancing effects.

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