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Introduction:   Psychiatric disorders, especially anxiety, are considered extraintestinal manifestations of celiac disease (CD).   Objective:   This study aims to evaluate the level of anxiety in treated patients with CD in Iran.   Methods:   A total of 283 CD patients (190 female, 93 male) were enrolled in a study during 2016–2018 from 9 centers in Iran. The Zung Self-Rating Anxiety Scale questionnaire was completed. The anxiety index was calculated. Also, demographic data and the duration of treatment with a gluten-free diet (GFD) were recorded. Data were analyzed by SPSS version 20.   Results:   Anxiety symptoms were reported in 67.8% of patients. Female patients had a higher anxiety index than male patients. Duration of treatment with a GFD did not influence the anxiety index (17.3% were on a GFD for <1 year, 33.6% for 1–2 years, and 49.1% had GFD for >2 years;  p  = 0.86).   Conclusions:   These results suggest that anxiety symptoms are common among patients, especially females, with CD in Iran and GFD duration has no effect on their improvement.

Anxiety Symptoms in Adult Celiac Patients and the Effect of a Gluten-Free Diet: An Iranian Nationwide Study