An Integrated View on Vascular Dysfunction in Alzheimer’s Disease | Zendy

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An Integrated View on Vascular Dysfunction in Alzheimer’s Disease

Author(s) -

Jan Klohs

Publication year - 2019

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000505625

Subject(s) - neuropathology , vascular dementia , medicine , endothelial dysfunction , dementia , neuroscience , cerebral blood flow , cognitive decline , vascular disease , hyperintensity , disease , pathology , psychology , magnetic resonance imaging , radiology

Cerebrovascular disease is a common comorbidity in patients with Alzheimer's disease (AD). It is believed to contribute additively to the cognitive impairment and to lower the threshold for the development of dementia. However, accumulating evidence suggests that dysfunction of the cerebral vasculature and AD neuropathology interact in multiple ways. Vascular processes even proceed AD neuropathology, implicating a causal role in the etiology of AD. Thus, the review aims to provide an integrated view on vascular dysfunction in AD.

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