Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms | Zendy

Brigitte K. Flesch | Zendy; Angelika Reil | Zendy; Núria Nogués | Zendy; Carme Saurina | Zendy; Peter Bugert | Zendy; Torsten J. Schulze | Zendy; Elly Huiskes | Zendy; Leendert Porcelijn | Zendy; Petter Höglund | Zendy; Paul Ratcliffe | Zendy; Marlies Schönbacher | Zendy; Hans Kerchrom | Zendy; Josina Kellershohn | Zendy; Behnaz Bayat | Zendy

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Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms

Author(s) -

Brigitte K. Flesch,

Angelika Reil,

Núria Nogués,

Carme Saurina,

Peter Bugert,

Torsten J. Schulze,

Elly Huiskes,

Leendert Porcelijn,

Petter Höglund,

Paul Ratcliffe,

Marlies Schönbacher,

Hans Kerchrom,

Josina Kellershohn,

Behnaz Bayat

Publication year - 2020

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000505523

Subject(s) - antigen , immunology , medicine , chemistry , computational biology , biology

The human neutrophil antigen 2 (HNA-2), which is expressed on CD177, is undetectable in 3-5% of the normal population. Exposure of these HNA-2 null individuals to HNA-2-positive cells can cause immunization and pro-duction of HNA-2 antibodies, which can induce immune neutropenia and transfusion-related acute lung injury. In HNA-2-positive individuals, neutrophils are divided into a CD177 pos. and a CD177 neg. subpopulation. The molecular background of HNA-2 deficiency and the bimodal expression pattern, however, are not completely decoded.

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