High-Throughput Screening of Blood Donors for Twelve Human Platelet Antigen Systems Using Next-Generation Sequencing Reveals Detection of Rare Polymorphisms and Two Novel Protein-Changing Variants | Zendy

Stephanie Maria Vorholt | Zendy; Nele Hamker | Zendy; Hagen Sparka | Zendy; Jürgen Enczmann | Zendy; T. Zeiler | Zendy; Tanja Reimer | Zendy; Johannes C. Fischer | Zendy; Vera Balz | Zendy

Open Access

High-Throughput Screening of Blood Donors for Twelve Human Platelet Antigen Systems Using Next-Generation Sequencing Reveals Detection of Rare Polymorphisms and Two Novel Protein-Changing Variants

Author(s) -

Stephanie Maria Vorholt,

Nele Hamker,

Hagen Sparka,

Jürgen Enczmann,

T. Zeiler,

Tanja Reimer,

Johannes C. Fischer,

Vera Balz

Publication year - 2020

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000504894

Subject(s) - genotyping , sanger sequencing , biology , taqman , allele , dna sequencing , single nucleotide polymorphism , genotype , neonatal alloimmune thrombocytopenia , amplicon , immunology , allele frequency , genetics , microbiology and biotechnology , gene , polymerase chain reaction , fetus , pregnancy

Exposure to non-matching human platelet alloantigens (HPA) may result in alloimmunization. Antibodies to HPA can be responsible for post-transfusion purpura, refractoriness to donor platelets, and fetal and neonatal alloimmune thrombocytopenia. For the supply of compatible apheresis platelet concentrates, the HPA genotypes are determined in a routine manner.

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