Advances in the Treatment of Cholinergic Anti-Inflammatory Pathways in Gastrointestinal Diseases by Electrical Stimulation of Vagus Nerve | Zendy

Wei Lei | Zendy; Zhijun Duan | Zendy

Open Access

Advances in the Treatment of Cholinergic Anti-Inflammatory Pathways in Gastrointestinal Diseases by Electrical Stimulation of Vagus Nerve

Author(s) -

Wei Lei,

Zhijun Duan

Publication year - 2019

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000504474

Subject(s) - inflammation , vagus nerve stimulation , cholinergic , vagus nerve , immune system , neuroscience , stimulation , medicine , gastrointestinal tract , immunology , proinflammatory cytokine , enteric nervous system , signal transduction , biology , pharmacology , microbiology and biotechnology

The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve (VN), modulates the immune system in the body. Recent studies of VN stimulation (VNS) in vivo systems have shown that it plays an anti-inflammatory role through CAIP. Inflammatory diseases in the gastrointestinal tract are frequent and difficult to treat.

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