Advanced Invasive Extramammary Paget’s Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism | Zendy

Kambayashi Yumi | Zendy; Fujimura Taku | Zendy; Ohuchi Kentaro | Zendy; Tono Hisayuki | Zendy; Ishida Yoshihiro | Zendy; Otsuka Atsushi | Zendy; Aiba Setsuya | Zendy

Open Access

Advanced Invasive Extramammary Paget’s Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism

Author(s) -

Kambayashi Yumi,

Fujimura Taku,

Ohuchi Kentaro,

Tono Hisayuki,

Ishida Yoshihiro,

Otsuka Atsushi,

Aiba Setsuya

Publication year - 2019

Publication title -

case reports in oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.365

H-Index - 19

ISSN - 1662-6575

DOI - 10.1159/000504339

Subject(s) - case report

Patients with invasive extramammary Paget’s disease have an increased risk of secondary malignancy, mostly occurring colorectal carcinoma. TP53 is a regulator of apoptosis, cell cycle arrest, and DNA damage response pathways, and has been reported as one of the genetic biomarkers for colorectal carcinoma. In this report, we describe a case of advanced invasive EMPD concomitant with cecal cancer with a rare variant of TP53 single nucleotide polymorphism (rs121912665). To our knowledge, there is no English report that presents EMPD concomitant with cecal carcinoma.

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