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Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease
Author(s) -
Shohei Hamada,
Eikichi Ihara,
Hiroko Ikeda,
Kazumasa Muta,
Haruei Ogino,
Takatoshi Chinen,
Yoshimasa Tanaka,
Yoshihiro Ogawa
Publication year - 2019
Publication title -
digestion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.882
H-Index - 75
eISSN - 1421-9867
pISSN - 0012-2823
DOI - 10.1159/000503340
Subject(s) - medicine , gastroenterology , gerd , reflux , refractory (planetary science) , heartburn , gastric acid , proton pump inhibitor , disease , stomach , physics , astrobiology
The newly developed vonoprazan (a potassium-competitive acid blocker) has a greater ability to suppress gastric acid production than convention proton pump inhibitors (PPIs). The objective of the present study was to determine how vonoprazan influences the pathogenesis of refractory gastroesophageal reflux disease (GERD) in clinical practice.

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