Loss of PTPN23 Promotes Proliferation and Epithelial-to-Mesenchymal Transition in Human Intestinal Cancer Cells | Zendy

Lisa van der Lely | Zendy; Janine Häfliger | Zendy; Ana MontalbanArques | Zendy; Katharina Bäbler | Zendy; Marlene Schwarzfischer | Zendy; Max Sabev | Zendy; Claudia Gottier | Zendy; Silvia Lang | Zendy; Michael Scharl | Zendy; Marianne R. Spalinger | Zendy

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Loss of PTPN23 Promotes Proliferation and Epithelial-to-Mesenchymal Transition in Human Intestinal Cancer Cells

Author(s) -

Lisa van der Lely,

Janine Häfliger,

Ana MontalbanArques,

Katharina Bäbler,

Marlene Schwarzfischer,

Max Sabev,

Claudia Gottier,

Silvia Lang,

Michael Scharl,

Marianne R. Spalinger

Publication year - 2019

Publication title -

inflammatory intestinal diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9403

pISSN - 2296-9365

DOI - 10.1159/000502861

Subject(s) - epithelial–mesenchymal transition , cancer research , gene silencing , biology , epidermal growth factor , signal transduction , colorectal cancer , cancer , cell signaling , carcinogenesis , cancer cell , microbiology and biotechnology , gene , cell culture , metastasis , genetics

Protein tyrosine phosphatase nonreceptor type 23 (PTPN23) has recently been associated with several human epithelial cancers via regulation of growth factor signaling. Colorectal carcinoma (CRC) is a leading cause for cancer-related death worldwide and is associated with aberrant epidermal (EGF) and vascular endothelial growth factor signaling. Here, we investigated whether PTPN23 might play a role in CRC.

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