Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis | Zendy

Phillip R. Purnell | Zendy; Benjamin Addicks | Zendy; Habib G. Zalzal | Zendy; Scott Shapiro | Zendy; Sijin Wen | Zendy; Hassan H. Ramadan | Zendy; Vincent Setola | Zendy; David P. Siderovski | Zendy

Open Access

Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis

Author(s) -

Phillip R. Purnell,

Benjamin Addicks,

Habib G. Zalzal,

Scott Shapiro,

Sijin Wen,

Hassan H. Ramadan,

Vincent Setola,

David P. Siderovski

Publication year - 2019

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000499875

Subject(s) - single nucleotide polymorphism , biology , genetics , minor allele frequency , allele , gene , snp , allele frequency , genetic association , population , genetic variation , genotype , medicine , environmental health

Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with altered innate immune responses to multiple bacterially derived signals.

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