Analysis of Endotoxin Adsorption in Two Swedish Patients with Septic Shock | Zendy

Marcus Broman | Zendy; Mikael Bodelsson | Zendy

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Analysis of Endotoxin Adsorption in Two Swedish Patients with Septic Shock

Author(s) -

Marcus Broman,

Mikael Bodelsson

Publication year - 2019

Publication title -

blood purification

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.686

H-Index - 57

eISSN - 1421-9735

pISSN - 0253-5068

DOI - 10.1159/000499546

Subject(s) - lipopolysaccharide , septic shock , chemistry , resuscitation , bacterial outer membrane , adsorption , shock (circulatory) , microbiology and biotechnology , membrane filter , in vivo , immunology , medicine , membrane , biology , sepsis , anesthesia , biochemistry , organic chemistry , escherichia coli , gene

Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine ethylene layer on the oXiris membrane is capable of adsorbing negatively charged endotoxin molecules and removing them from the blood compartment. Endotoxin is detrimental and should be removed from blood.

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